Syncona quarterly update: Net assets and portfolio value increase, key milestones achieved by portfolio companies

Syncona Limited
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Syncona Limited (LON:SYNC), a leading life science investor focused on creating, building and scaling global leaders in life science, has issued its quarterly update covering the period from 01 October to 31 December 2023.

Financial performance in the quarter

· Net assets of £1,251.0 million (30 September 2023: £1,201.3 million), equivalent to 188.2p per share (30 September 2023: 178.6p per share)

· NAV per share return of 5.4% in the period, driven by a £111.1 million increase in the value of Autolus Therapeutics (Autolus), outweighing the partial write down of the Company’s holding in Anaveon to £24.9 million (£42.8 million decline in value), which reflects the company’s decision to focus on its next generation, pre-clinical programme

· Life science portfolio valued at £699.8 million (30 September 2023: £620.9 million), a return of 9.7% in the quarter[1]

· Over the nine months to 31 December 2023, NAV per share has returned 0.9% with the life science portfolio generating a return of 3.0%

· Capital pool of £551.2 million at 31 December 2023 (30 September 2023: £580.4 million)

o £18.5 million deployed into the life science portfolio in the quarter and £77.2 million in the nine months to 31 December 2023

o £(4.6) million impact from foreign exchange movements across the capital pool[2]

o £9.9 million of shares repurchased at an average discount of 33.8% resulting in a 0.76p accretion to NAV per share in the quarter[3]

69% of value in the strategic life science portfolio in clinical-stage companies with late-stage clinical companies making good progress

· Portfolio of 13 companies with six at clinical stage, including two late-stage clinical

· Nine clinical data read outs in the period including positive data published from two late-stage companies, Autolus and Beacon Therapeutics (Beacon)

· Autolus achieved an important strategic milestone filing its Biologics License Application (BLA) with the Food and Drug Administration (FDA) for obe-cel in relapsed/refractory (r/r) adult acute lymphoblastic leukaemia (ALL)

o The filing was accepted post-period end and the FDA is expected to make a decision on approval in November 2024

· The University of Edinburgh published data from an academic study, which will support Resolution Therapeutics’ (Resolution) upcoming entry into a Phase I/II clinical trial in its lead macrophage cell therapy programme

· Post-period end, Freeline Therapeutics (Freeline) announced further data from the company’s Gaucher disease programme, which was supportive of the efficacy and safety profile of the company’s FLT201 gene therapy

Prioritising capital access across the portfolio to enable delivery of key value inflection points

· Continuing challenging macro conditions have significantly impacted the financing environment for life science companies

· Syncona’s capital pool provides the flexibility to prioritise capital towards clinical stage assets

· The Syncona team continues to take proactive and decisive action across the portfolio to maximise value:

o Anaveon has taken the strategic decision to focus on its next generation compound ANV600

o Reflecting that its next generation programme ANV600 is pre-clinical (ANV419 was clinical), Syncona and the syndicate of investors in Anaveon have adjusted the price of the final tranche of CHF 36.2 million (£32.8 million)[4] of the 2021 Series B financing which is also aligned with current market conditions, resulting in a write down of the Company’s holding in Anaveon to £24.9 million, a £42.8 million decline in value

o The strategic actions ensure Anaveon is now funded to deliver the key value inflection point of its clinical data readout from its Phase I/II trial of ANV600 in CY2026

o Syncona believes in the potential of Anaveon’s next generation compound, which is supported by the positive pre-clinical data available to date

o A newly established portfolio company of Syncona entered into an agreement with Freeline to acquire all of the shares of Freeline that Syncona does not own in an all-cash transaction. Syncona continues to be encouraged by the data published by Freeline in its FLT201 programme and is pleased with how the company is executing

o The acquisition is subject to approval or acceptance by the required number of Freeline’s minority shareholders and is expected to close in the first quarter of 2024, with a General Meeting in which shareholders will vote on the proposed acquisition scheduled for 12 February 2024

· The impact of the current financing environment is specific to the stage and progress of each individual portfolio company. Syncona is focused on ensuring capital efficiency in its portfolio and ensuring portfolio companies are executing to deliver key milestones

· Where appropriate Syncona continues to focus on widening financing syndicates and exploring creative financing options for portfolio companies

· Continuing to work with portfolio company co-investors to fund companies through to achieving positive clinical and operational progress

· Syncona is funded to deliver expected milestones and value inflection points in the portfolio that it believes have the potential to drive access to capital and NAV growth

Focus on identifying transformational science to deliver long-term growth

· In advanced stages of diligence in two new opportunities in oncology; with one an early-stage opportunity and the second a clinical stage company

· Continued focus on clinical stage opportunities to add to our maturing portfolio and drive near-term growth

Operational and Governance changes

· Rolf Soderstrom, Chief Financial Officer (CFO) of Syncona Investment Management Limited (SIML) is moving to the role of Executive Partner, where he will support the Leadership and Investment teams whilst remaining on the Board of SIML and as Chair of the Valuation Committee

· Kate Butler, Group Finance Director of SIML will take up the role of CFO of SIML, effective 1 April 2024. Kate joined Syncona in September 2022 and brings with her a wealth of experience from previous finance leadership roles at Vectura Group plc and Gilead Sciences, Inc.

· During the period, Martin Murphy also stepped down as Chair of SIML with Chris Hollowood holding the role of Interim Chair; Martin continues to represent Syncona on the Boards of Autolus, Anaveon and Clade Therapeutics

Chris Hollowood, Chief Executive Officer, Syncona Investment Management Limited, said: “We have continued to take decisive action to support our companies’ ability to deliver on their next key clinical milestones to maximise value across the portfolio against a continuing challenging market backdrop in the third quarter. We have been pleased with the recent clinical and regulatory progress at Autolus, which we believe is now being reflected in its recent positive share price performance. Whilst the macroeconomic outlook is starting to look more favourable with conditions improving in the public markets, we continue to see the private markets under pressure especially in earlier stage assets and where companies are financing ahead of delivering key milestones. We are focused on funding our companies to their next key clinical data points to drive long-term value and whilst the pricing of the recent investment tranche in Anaveon has led to a partial write-down in our holding, the company is now well positioned to deliver clinical data from its next generation asset.

We have also continued to evolve our operating model with Rolf moving to Executive Partner bringing his broad experience to support our strategic ambitions whilst maintaining his governance role at the SIML Board. I would like to thank Rolf for his support in developing the strategy and operations for the next phase of Syncona’s growth and his leadership of our Finance team to support our growth ambitions. I look forward to working with Kate who brings both extensive finance and life science experience and congratulate her on her well-deserved promotion to CFO.

Looking ahead, we have six key value inflection points over the next 12-36 months with the potential to drive significant NAV growth and are funded to deliver these. We will continue to take a rigorous approach to capital allocation and portfolio management, whilst also continuing to fuel our long-term growth by creating new companies across the new frontier of science.”

Outlook

Capital deployment guidance

The Company continues to anticipate that deployment into the portfolio and pipeline at financial year end will be £150-200 million, in line with prior guidance. This excludes the £40.0 million of capital allocated to the share buyback.

Portfolio milestones and potential value inflection points

· 11 expected milestones across the portfolio over the next 12 months which have the potential to enable capital access

· Six key value inflection points which have the potential to drive significant NAV growth over the next 12-36 months

· These milestones and value inflection points are not without risk

Strategic life science portfolioNext expected milestones with the potential to enable capital accessSyncona view of potential value inflection points across the portfolio
Moving towards being on the market
AutolusH1 CY2024
–       Initiate a Phase I study of obe-cel in refractory systemic lupus erythematosus (SLE), extending the use of obe-cel into autoimmune diseases H2

CY2024
–       Provide initial data from the Phase I trial in SLE 

CY2024
–       Commence the US commercial launch of obe-cel, dependent on anticipated FDA regulatory approval in November
CY2025
–       Traction following US commercial launch of obe-cel, dependent on FDA regulatory approval 
BeaconH1 CY2024
–       Publish 12-month data from its Phase II SKYLINE trial in XLRP
–       Initiate its Phase II/III trial in XLRP
H2 CY2024
–       Present 24-month data from its Phase II SKYLINE trial in XLRP
Moving towards publishing definitive data
FreelineH2 CY2024
–       Release of additional data from its Phase I/II trial in Gaucher disease 
ResolutionH2 CY2024
–       Enter the clinic in a Phase I/II trial in liver cirrhosis
CY2026
–       Completion of Phase I/II trial in liver cirrhosis
Moving towards publishing emerging efficacy data
AchillesQ1 CY2024
–       Provide further data from its Phase I/IIa clinical trial in NSCLC
–       Provide further data from its Phase I/IIa clinical trial in melanoma
QuellH1 CY2024
–       Initial safety data in Phase I/II trial in liver transplantation
CY2025
–       Proof of concept data from its Phase I/II trial in liver transplantation
SwanBioH2 CY2024
–       Initial safety readout in higher dose cohort from its Phase I/II trial in AMN-     
  
AnaveonH2 CY2024
–       Initiate a Phase I/II trial of ANV600, the company’s next generation compound
CY2026
–       Interim clinical data readout from its Phase I/II trial of its next generation asset ANV600

Valuation movements in the quarter

Company30 Sep 2023Net investment in the periodValuationchangeFX movement31 Dec 2023% of Group NAVValuationbasis[5],[6],[7]Fully diluted owner-ship stakeFocus area 
(£m)(£m)(£m)(£m)(£m) 
Strategic portfolio companies 
Late-stage clinical 
Autolus64.0111.1(5.5)169.613.5%Quoted17.5%Cell therapy 
Beacon75.075.06.0%PRI65.3%Gene therapy 
Clinical 
Quell87.7(3.7)84.06.7%PRI33.7%Cell therapy 
SwanBio77.40.6(3.4)74.66.0%Cost80.0%Gene therapy 
Freeline8.88.04.5(0.7)20.61.6%Quoted/cost[8]49.7%Gene therapy 
Achilles8.3(0.2)(0.3)7.80.6%Quoted24.5%Cell therapy 
Pre-clinical 
Purespring35.19.90.145.13.6%Cost82.9%Gene therapy 
OMass43.743.73.5%PRI32.7%Small molecules 
Resolution37.937.93.0%Cost81.6%Cell therapy 
Anaveon64.9(42.8)2.824.92.0%PRI37.9%Biologics 
Clade24.6(1.1)23.51.9%Cost21.7%Cell therapy 
Kesmalea12.012.01.0%Cost71.8%Small molecules 
Mosaic7.37.30.6%Cost52.4%Small molecules 
Portfolio milestones and deferred consideration 
Beacon deferred consideration14.00.4(0.6)13.81.1%DCFGene therapy 
Neogene milestone payment2.20.1(0.1)2.20.2%DCFCell therapy 
Syncona investments 
CRT Pioneer Fund32.90.633.52.7%Adj Third Party64.1%Oncology 
Biomodal[9]18.7(0.8)17.91.4%PRI5.5%Epigenetics 
Forcefield5.55.50.4%Cost82.0%Biologics 
Adaptimmune0.90.90.1%Quoted0.8%Cell therapy 
Total Life Science Portfolio620.918.573.8(13.4)699.855.9%    
 
Capital pool580.4(34.4)9.8(4.6)551.244.1%    
TOTAL1,201.3   1,251.0100%    
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