Oncimmune Holdings Agreement signed with major cancer center

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Oncimmune Holdings plc (LON:ONC), the leading global immunodiagnostics group, today announces it has signed an autoantibody profiling contract with Dana-Farber Cancer Institute (“Dana-Farber”) in Boston, Massachusetts. Dana-Farber, a clinical affiliate and research institute of Harvard Medical School, is a world-leading cancer research organisation and one of America’s top-rated cancer hospitals with more than 1,100 therapeutic and non therapeutic clinical trials in progress.

Under this agreement, Oncimmune will be utilising its proprietary biomarker discovery engine, SeroTag^TM, to identify autoantibodies that can be predictive of patient response or associated with resistance to checkpoint inhibitors (“CPIs”) and chemotherapy used in Dana-Farber led studies or therapy using atezolizumab, nivolumab, pembrolizumab, durvalumab and cisplatin-based chemotherapy. In addition, SeroTag will be used for identifying autoantibodies that can be predictive of immune-related adverse events (“irAEs”) in response treatment. The project is scheduled to complete by the end of 2021.

SeroTag is a high-throughput, multiplex, discovery technology based on Oncimmune’s in-house protein library, one of the largest in the world, with a unique, ever-growing repository of disease data for indications such as autoimmune and infectious diseases as well as cancer. The proprietary SeroTag immuno-oncology discovery array is based on autoantibody profiling studies in autoimmune diseases and other cancer types, and comprises known and proprietary antigens linked to a number of cancers, autoimmune and infectious diseases.

Dr Adam M Hill, CEO of Oncimmune Holdings said: “We are delighted to be partnering with such a prestigious organisation as Dana-Farber on the use of multiple CPI assets in this important oncology trial and leveraging the power of our autoantibody biomarker profiling technology.
“As autoantibodies continue to be recognised as a key biomarker class that aid in the understanding of interactions between cancer and the immune system, the ImmunoINSIGHTS platform is becoming increasingly instrumental in studies for a wide range of cancer indications and therapy classes.”