Indivior PLC (LON: INDV) today announced the launch of once-monthly PERSERISTM (risperidone) for extended-release injectable suspension in the United States. PERSERIS is approved by the U.S. Food and Drug Administration for the treatment of schizophrenia in adults. PERSERIS delivers its active ingredient, risperidone, in an extended-release delivery system with no loading doses or oral supplementation recommended.1
Schizophrenia is a chronic and severe mental disorder that requires ongoing treatment to manage symptoms.2 People with schizophrenia are often unable to perceive their illness, which is a key reason they stop taking their medication.3,4,5 Long-acting injectable antipsychotics, including PERSERIS, provide patients with steady-state plasma concentrations of active drug that remain within a therapeutic range for an extended period.6
“Schizophrenia is a complex disease and part of the complexity is that a patient may not recognise that they are ill and therefore not see the need to take medicine,” said Anne Andorn, MD, Chief Medical Officer at Indivior. “PERSERIS is a once-monthly injection of a commonly prescribed medication known to reduce symptoms of schizophrenia and does not depend on the patient taking additional oral medication. Reducing the symptoms of schizophrenia is very important to help reduce the abnormal behaviours that can lead to the stigma of this disease.”
PERSERIS uses an extended-release delivery system to form a depot under the skin following abdominal subcutaneous administration by a healthcare provider. Risperidone is released on initial depot formulation followed by sustained release from the depot over an entire month. Initial peak levels of risperidone occur in four to six hours of dosing.1 Before starting PERSERIS, physicians should establish tolerability with oral risperidone in patients who have never taken it before. Patients on stable doses of oral risperidone lower than 3 mg or higher than 4 mg a day may not be candidates for PERSERIS.
“With the launch of PERSERIS, Indivior continues to focus on delivering innovative treatments that address patient needs,” said Shaun Thaxter, Chief Executive Officer of Indivior. “PERSERIS helps treatment initiation while also eliminating the need for daily antipsychotic medication dosing.”
Indivior is committed to helping ensure our products are affordable to patients. A PERSERIS co-pay assistance program will be available to eligible patients. Eligible patients may pay as little as $5 each month. The INSUPPORT Copay Assistance Program is valid only for patients with private insurance who are prescribed PERSERIS for on-label use. Patients with government insurance (government insurance includes, but is not limited to, Medicare, Medicaid, Medigap, VA, DoD, TRICARE, CHAMPVA, or any other federally or state-funded, government-assisted program) are not eligible for the Copay Assistance Program. Other restrictions may apply. Visit www.INSUPPORT.com for full terms and conditions and more information.
